ScienceDaily (2010-11-08) -- Using a blend of brain imaging and genetic detective work, scientists have illustrated how genetic variants rewire the brain. The discovery offers the crucial missing physical evidence that links altered genes to modified brain function and learning.
"In children who carry the risk gene, the front of the brain appears to talk mostly with itself," explained first author Ashley Scott-Van Zeeland, now a Dickinson Research Fellow at Scripps Translational Science Institute. "It doesn't communicate as much with other parts of the brain and lacks long-range connections to the back of the brain."
Researchers could test whether specific therapies actually change brain function by measuring connectivity of patients before and after therapy, she added.
The authors emphasized that the patterns of connectivity found in the study still fall along the spectrum of normal gene variation. "One third of the population carries this variant in its DNA," noted Geschwind. "It's important to remember that the gene variant alone doesn't cause autism, it just increases risk."
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